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CORE COMPONENT 1:
Administrative

Dorit Ron, PhD, Center Director
Howard Fields, MD, PhD, Scientific Director

The Administrative Core manages all aspects of administration and scientific activities, planning, budget, training, educational enrichment, and program evaluation for all components of the ACGT. The Executive Committee, comprised of the Center and Component Directors, is responsible for evaluating program and component progress, and quality control.

Scientific oversight is provided by the Program Advisory Committee (PAC), which serves as a scientific advisory board for the ACGT. Members of the PAC were selected based on expertise pertinent to the research components and aims of the ACGT. Members serve three-year renewable terms.

John C. Crabbe, PhDDirector, Portland Alcohol Research Center
Professor of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR
David M. Lovinger, PhDChief, Laboratory of Integrative Neuroscience,NIAAA, Rockville, MD
Richard Palmiter, PhDProfessor of Biochemistry, Investigator at HHMI, University of Washington, Seattle, WA
Gary S. Aston-Jones, PhDProfessor and Murray Chair of Excellence in Neuroscience, Medical University of South Carolina, Charleston, SC


CORE COMPONENT 2:
Animal and Behavior

Frederic “Woody” Hopf, PhD, Director

The Animal and Behavior Core provides services, technical assistance and training needed for the breeding and behavioral testing of the knockout and knock-in mice to be examined by the investigators within the ACGT research components. Centralized breeding and genotyping maximizes efficiency and allows for the development and use of a centralized system for tracking the production and use of all mice created under this center. In addition, the Animal and Behavior Core is standardizing the methods and analyses for alcohol-related behavioral testing for mice and rats.

A series of behavioral tests evaluates the acute sedating and ataxic effects of alcohol, as well as the reinforcing and rewarding properties of alcohol, in mice generated by the research components. The Animal and Behavior Core also instructs research personnel in the conduct of other behavioral studies, as needed. By conducting the bulk of the behavioral testing within the core, we ensure that the procedures are performed, and the data are analyzed, in a consistent manner, allowing for maximal comparability of the effects of different genetic manipulations across center projects.

CORE COMPONENT 3:
Vector, Transgenic and Imaging Core

Kevin Bender, PhD, Director
Viktor Kharazia, PhD, Co-Director

The Transgenic and Imaging Core supports projects that use conditional knockout genes by maintaining and generating mouse lines that express Cre recombinase, and generates viral vectors for gene silencing by RNA interference and viruses for transgenic expression of proteins in select brain regions. Core personnel assist investigations of the cellular localization of target proteins and their partners in protein-protein interactions by performing immunohistochemistry, laser capture microdissection and visualization of reporter genes. The Core also provides oversight of imaging equipment, training in viral vector production techniques, histology, imaging and image processing, generates standard procedures for techniques used by the Core, and explores new technologies for regulating gene silencing in mice and rats, and the development of mouse lines that express inducible Cre recombinase in limbic brain regions.

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