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© Skidmore, Owings & Merrill LLP | Cesar Rubio, 2012. All rights reserved.

Publications

Blegen M, da Silva E Silva DA, Bock R, Morisot N, Ron D, Alvarez V. Alcohol operant self-administration: Investigating how alcohol seeking behaviors predicts drinking in mice using two operant approaches. Alcohol. Accepted

Phamluong K, Darcq E, Wu S, Sakhai S, Ron D. Fyn Signaling Is Compartmentalized To Dopamine D1 Receptor Expressing Neurons In The Dorsal Medial Striatum. Frontiers Molecular Neuroscience Accepted.

Morisot N, Novotny C.J., Shokat KM and Ron D. A new generation of mTORC1 inhibitor attenuates alcohol intake and reward in mice. Addiction Biology. 2017 Jul 6. [Epub ahead of print]

Rinetti G, Phamluong K, Ron D, Bender KJ. Periadolescent maturation of GABAergic hyperpolarization at the axon initial segment. Cell Reports. Cell Rep. 2017 Jul 5;20(1):21-29.

Rodrik-Outmezguine VS, Okaniwa M, Yao Z, Novotny CJ, McWhirter C, Banaji A, Won H, Wong W, Berger M, de Stanchina E, Barratt DG, Cosulich S, Klinowska T, Rosen N, Shokat KM. Overcoming mTOR Resistance Mutations with a New Generation mTOR Inhibitor. Nature. 2016 Jun 9;534(7606):272-6

Beckley, J.T., Laguesse S., Phamluong K., Morisot N., Wegner S.A., D. Ron. The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons. J Neurosci 36, 701-13, 2016.

Blasio A, Messing RO. Binge Drinking With Protein Kinase C Epsilon: A Role for Mammalian Target of Rapamycin Complex 2? Commentary. Bol Psychiatry. 2016 Mar 15;79(6):425-6.

Liu, F., Laguesse S., Legastelois R., Morisot N., Ben Hamida S., D. Ron. mTORC1-dependent Translation of Collapsin Response Mediator Protein-2 Drives Neuroadaptations Underlying Excessive Alcohol Drinking Behaviors. Molecular Psychiatry 2016 Mar 8.[Epub ahead of print].

Maiya R, McMahon T, Wang D, Kanter B, Gandhi D, Chapman HL, Miller J, Messing RO. Selective chemical genetic inhibition of protein kinase C epsilon reduces ethanol consumption in mice. Neuropharmacology. 2016 Mar 3;107:40-48 [Epub ahead of print].

Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D. The BDNFVal68 to Met Polymorphism Increases Compulsive Alcohol Drinking In Mice Which Is Reversed By TrkB Activation. Biol Psychiatry. 79(6):463-73, 2015.
       Commentary: Pandey S.C, Biol Psychiatry. 15;79(6):427-9, 2016.

Wang J, Cheng Y, Wang X, Hellard ER, Ma T, Gil H, Ben Hamida S, and Ron D. Alcohol Elicits Functional and Structural Plasticity Selectively in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum. J. Neurosci. 35(33): 11634-11643, 2015.

Pomrenze MB, Millan EZ, Hopf FW, Keiflin R, Maiya R, Blasio A, Dadgar J,Kharazia V, De Guglielmo G, Crawford E, Janak PH, George O, Rice KC, Messing RO. A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits. Front Neurosci. 2015 Dec 24;9:487.

Seif T, Simms JA, Lei K, Wegner S, Bonci A, Messing RO, Hopf FW. D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats. Neuropsychopharmacology. 2015 Sep;40(10):2357-67. doi: 10.1038/npp.2015.84. Epub 2015 Mar 24.

Logrip ML, Barak S, Warnault V, Ron D. Corticostriatal BDNF and alcohol addiction. Brain Res. 1628:60-7. 2015.

Neasta J, Barak S, Ben Hamida S, Ron D. mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse. Journal of neurochemistry. 2014 Jul, 130 (2):172-84.

Trudell JR, Messing RO, Mayfield J, Harris RA. Alcohol dependence: molecular and behavioral evidence. Trends in pharmacological sciences. 2014 Jul, 35 (7):317-23.

Darcq E, Ben Hamida S, Wu S, Phamluong K, Kharazia V, Xu J, Lombroso P, Ron D. Inhibition of striatal-enriched tyrosine phosphatase 61 in the dorsomedial striatum is sufficient to increased ethanol consumption. Journal of neurochemistry. 2014 Jun, 129 (6):1024-34.

Carnicella S, Ron D, Barak S. Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse. Alcohol (Fayetteville, N.Y.). 2014 May, 48 (3):243-52.

Becker HC, Ron D. Animal models of excessive alcohol consumption: recent advances and future challenges. Alcohol (Fayetteville, N.Y.). 2014 May, 48 (3):205-8.

King IFG, Eddison M, Kaun Ka R, Heberlein U. EGFR and FGFR pathways have distinct roles in Drosophila mushroom body development and ethanol-induced behavior. PloS one. 2014, 9 (1):e87714.

Steinberg EE, Boivin JR, Saunders BT, Witten IB, Deisseroth K, Janak PH. Positive reinforcement mediated by midbrain dopamine neurons requires D1 and D2 receptor activation in the nucleus accumbens. PloS one. 2014, 9 (4):e94771.

Warnault V, Ron D. Chromatin remodeling: a new landscape to treat harmful alcohol-use disorders. Future medicinal chemistry. 2013 Nov, 5 (17):2011-3.

Ben Hamida S, Darcq E, Wang J, Wu S, Phamluong K, Kharazia V, Ron D. Protein tyrosine phosphatase * in the dorsomedial striatum promotes excessive ethanol-drinking behaviors. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2013 Sep 4, 33 (36):14369-78.

Lee AM, Zou ME, Lim JP, Stecher J, McMahon T, Messing RO. Deletion of Prkcz Increases Intermittent Ethanol Consumption in Mice. Alcoholism, clinical and experimental research. 2013 Aug 1.

Barak S, Liu, Feng, Ben Hamida S, Yowell QV, Neasta J, Kharazia V, Janak PH, Ron D. Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. Nature neuroscience. 2013 Aug, 16 (8):1111-7.

Seif T, Chang S-J, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW. Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nature neuroscience. 2013 Aug, 16 (8):1094-100.

van Rijn RM, Defriel JN, Whistler JL. Pharmacological traits of delta opioid receptors: pitfalls or opportunities? Psychopharmacology. 2013 Jul, 228 (1):1-18.

Steinberg EE, Keiflin R, Boivin JR, Witten IB, Deisseroth K, Janak PH. A causal link between prediction errors, dopamine neurons and learning. Nature neuroscience. 2013 Jul, 16 (7):966-73.

Jee C, Lee J, Lim JP, Parry D, Messing, RO, McIntire SL. SEB-3, a CRF receptor-like GPCR, regulates locomotor activity states, stress responses and ethanol tolerance in Caenorhabditis elegans. Genes, brain, and behavior. 2013 Mar, 12 (2):250-62.

Kapfhamer D, Taylor S, Zou ME, Lim JP, Kharazia V, Heberlein U. Taok2 controls behavioral response to ethanol in mice. Genes, brain, and behavior. 2013 Feb, 12 (1):87-97.

Lee AM, Kanter BR, Wang D, Lim JP, Zou ME, Qiu C, McMahon T, Dadgar J, Fischbach-Weiss SC, Messing RO. Prkcz null mice show normal learning and memory. Nature. 2013 Jan 17, 493 (7432):416-9.

van Rijn RM, Harvey JH, Brissett DI, DeFriel JN, Whistler JL. Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling. The Journal of pharmacology and experimental therapeutics. 2013 Jan, 344 (1):179-88.

Ron D, Messing RO. Signaling pathways mediating alcohol effects. Current topics in behavioral neurosciences. 2013, 13:87-126.

Warnault V, Darcq E, Levine A, Barak S, Ron D. Chromatin remodeling--a novel strategy to control excessive alcohol drinking. Translational psychiatry. 2013, 3:e231.

Ron D, Adams DR, Baillie GS, Long A, O'Connor R, Kiely PA. RACK1 to the future--a historical perspective. Cell communication and signaling: CCS. 2013, 11:53.

Ben Hamida S, Neasta J, Lasek AW, Kharazia V, Zou M, Carnicella S, Janak PH, Ron D. The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2012 Nov 7, 32 (45):15849-58.

Wang J, Ben Hamida S, Darcq E, Zhu W, Gibb SL, Lanfranco MF, Carnicella S, Ron D. Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2012 Oct 24, 32 (43):15124-32.

Mitchell JM, Margolis EB, Coker AR, Fields HL. Alcohol self-administration, anxiety, and cortisol levels predict changes in delta opioid receptor function in the ventral tegmental area. Behavioral neuroscience. 2012 Aug, 126 (4):515-22.

Brissett DI, Whistler L, van Rijn RM. Contribution of mu and delta opioid receptors to the pharmacological profile of kappa opioid receptor subtypes. European journal of pain (London, England). 2012 Mar, 16 (3):327-37.

van Rijn RM, Brissett DI, Whistler JL. Emergence of functional spinal delta opioid receptors after chronic ethanol exposure. Biological psychiatry. 2012 Feb 1, 71 (3):232-8.

van Rijn RM, Brissett DI, Whistler JL. Distinctive modulation of ethanol place preference by delta opioid receptor-selective agonists. Drug and alcohol dependence. 2012 Apr 1, 122 (1-2):156-9.

Kapfhamer D, King I, Zou ME, Lim JP, Heberlein U, Wolf FW. JNK pathway activation is controlled by Tao/TAOK3 to modulate ethanol sensitivity. PloS one. 2012, 7 (12):e50594.

Witten IB, Steinberg EE, Lee SY, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong , S, Ramakrishnan C, Stuber GD, Tye KM, Janak PH, Deisseroth K. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron. 2011 Dec 8, 72 (5):721-33.

Neasta J, Ben Hamida S, Yowell QV, Carnicella S, Ron D. AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors. Biological psychiatry. 2011 Sep 15, 70 (6):575-82.

Margolis EB, Mitchell JM, Hjelmstad GO, Fields HL. A novel opioid receptor-mediated enhancement of GABAA receptor function induced by stress in ventral tegmental area neurons. The Journal of physiology. 2011 Sep 1, 589 (Pt 17):4229-42.

King I, Tsai LT-Y, Pflanz R, Voigt A, Lee S, Jackle H, Lu B, Heberlein U. Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2011 Jan 19, 31 (3):1139-48.

Carnicella S, Yowell QV, Ron D. Regulation of operant oral ethanol self-administration: a dose-response curve study in rats. Alcoholism, clinical and experimental research. 2011 Jan, 35 (1):116-25.

Neasta J, Ben Hamida S, Yowell, Quinn, Carnicella S, Ron D. Role for mammalian target of rapamycin complex 1 signaling in neuroadaptations underlying alcohol-related disorders. Proceedings of the National Academy of Sciences of the United States of America. 2010 Nov 16, 107 (46):20093-8.

van Rijn RM, Brissett DI, Whistler JL. Dual efficacy of delta opioid receptor-selective ligands for ethanol drinking and anxiety. The Journal of pharmacology and experimental therapeutics. 2010 Oct, 335 (1):133-9.

Kong EC, Allouche L, Chapot PA, Vranizan K, Moore MS, Heberlein U, Wolf FW. Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. Alcoholism, clinical and experimental research. 2010 Feb, 34 (2):302-16.

Newton PM, Messing RO. The substrates and binding partners of protein kinase Cepsilon. The Biochemical journal. 2010 Apr 15, 427 (2):189-96.

Lee AM, Messing RO. Protein kinases and addiction. Annals of the New York Academy of Sciences. 2008 Oct, 1141:22-57.

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